Linc01614 Regulates the Proliferation, Apoptosis, and Chemotherapy Resistance in Esophageal Squamous Cell Carcinoma by Targeting Mir-4775

Background: Esophageal squamous cell carcinoma (ESCC), a widely known esophageal disease, severely affects people's health. Numerous investigations demonstrated that long non-coding RNAs (lncRNAs) performed key jobs inside wide scope of organic cycles and stand out in malignant growth. Our study planned to investigate the roles mechanisms linc01614 ESCC.
 Methods: A Total 60 ESCC tissue samples including 30 patients with cisplatin sensitivity resistance, who received DDP-based treatment, were obtained from Zhuhai People's Hospital, City during 2021. These tissues frozen saved -80 ℃ ultra-low temperature freezer. We CCK-8, clone formation, flow cytometry assays determine effect on progression, explored specific mechanism proliferation, apoptosis, chemotherapy resistance.
 Results: expression was upregulated cells compared non-tumor human normal epithelial (Het-1A). Knockdown repressed expansion, opposition, advanced apoptosis ESCC. Besides, regulated miR-4775 as competitive endogenous RNA (ceRNA).
 Conclusion: The linc01614/miR-4775 axis played an important role progression drug revealing is promising target treatment.